“Unveiling the role of spirulina in the mitigation of sumithion-induced growth retardation, oxidative stress and immuno-toxicity in striped catfish (pangasianodon hypophthalmus) (6977)”

unveiling the role of spirulina in the mitigation of sumithion-induced growth retardation, oxidative stress and immuno-toxicity in striped catfish (pangasianodon hypophthalmus)

sumithion is an organophosphate insecticide, widely used in aquaculture ponds to eradicate aquatic insect (mainly tiger bugs), typically applied before stocking fish larvae. however, it adversely affects non-target aquatic organisms, particularly fish. this study was conducted to evaluate the potential toxicity of sumithion in thai pangas (pangasianodon hypophthalmus) as well as the role of dietary spirulina (spirulina platensis) in mitigating the toxic effects of sumithion. over a 42-day trial, a total 240 of striped catfish fingerlings were exposed to four different treatments: control (without sumithion or spirulina), sumithion (0.6 mg/l), spirulina (50 g/kg feed) and combined treatment (sumithion + spirulina) with three replicates each. sumithion treated fish exhibited altered hemato-biochemical indices (haemoglobin and glucose) as well as erythrocyte morphology abnormalities—cellular (teardrop, twin, fusion) and nuclear (nuclear bridge, nuclear buds, notch, karyopyknosis); the intestinal structure was compromised, growth indices (wg, sgr %/day) were reduced, and fcr increased in sumithion treated fish. in contrast, spirulina—either alone or in combination with sumithion—significantly improved intestinal architecture, growth performance and feed efficiency. furthermore, sumithion exposure induced marked shifts in gene expression: antioxidant genes sod and cat were down regulated while gpx was up regulated, and immune related genes mhc ii and ifn β2 were up regulated whereas il 1β and ifn α2 were down regulated compared to control; spirulina supplementation reversed these trends, enhancing both immune and antioxidant gene responses. the current study thus demonstrates that dietary spirulina efficiently mitigates sumithion induced stress and promotes overall health in striped catfish by restoring hemato biochemical indices, intestinal integrity, growth performance and immune antioxidant gene expression.

1. BINTE ASHRAF, SAUDAH, LABORATORY OF FISH ECOPHYSIOLOGY,BANGLADESH AGRICULTURAL UNIVERSITY, Presenter
2. Amin, Md Ruhul, LABORATORY OF FISH ECOPHYSIOLOGY,BANGLADESH AGRICULTURAL UNIVERSITY, Author
3. Shahjahan, Md, LABORATORY OF FISH ECOPHYSIOLOGY,BANGLADESH AGRICULTURAL UNIVERSITY, Author